Satkhira (Bengali: সাতক্ষীরা জেলা, pron: Satkhira) is a district in southwestern Bangladesh and is part of Khulna Division. It lies along the border with West Bengal, India. It is on the bank of the Arpangachhia River. The largest city and headquarter of this district is Satkhira.

Satkhira District has an area of about 3817.29 km². It is bordered to the north by Jessore District, on the south by the Bay of Bengal, to the east by Khulna District, and to the west by 24 Pargana District of West Bengal, India.

The annual average maximum temperature reaches 35.5 °C (95.9 °F); minimum temperature is 12.5 °C (54.5 °F). The annual rainfall is 1710 mm (67 in).

The main rivers are the Kopotakhi river across Dorgapur union of Assasuni Upazila, Morichap River, Kholpetua River, Betna River, Raimangal River, Hariabhanga river, Ichamati River, Betrabati River and Kalindi-Jamuna River.

According to the 2011 Bangladesh census, Satkhira District had a population of 1,985,959. Males constituted 49.49% of the population and females 50.51%. Muslims formed 81.86% of the population, Hindus 17.70%, Christians 0.31% and others 0.12%. Satkhira District had a literacy rate of 52.07% for the population 7 years and above.